by The No. 16 Notre Dame Fighting Irish will look to get a much-needed win over a ranked opponent when they host the No. 15 Louisville Cardinals on Saturday afternoon. Notre Dame suffered a shocking loss to Northern Illinois on September 7, but the Fighting Irish have outscored their opponents 94-10 in their past two games. Louisville, meanwhile, heads into Saturday’s showdown with an undefeated record. The Cardinals posted a 31-19 win over Georgia Tech in their last outing.
Kickoff at Notre Dame Stadium is scheduled for 3:30 PM ET. The Fighting Irish are favored by 6.5 points in the latest Louisville vs. Notre Dame odds via SportsLine consensus, while the over/under for total points scored is 45.5. Before you make your pick between Notre Dame and Louisville, be sure to check out the college football predictions and betting advice from SportsLine’s projection model.
The model simulates every FBS college football game 10,000 times. Since its inception, it has generated over $2,000 in profits for $100 players on its top-rated college football picks against the spread. It’s also posting a profitable 13-9 season based on top-rated spread picks. Anyone who has followed it has seen strong returns.
Now the model has set its sights on Notre Dame versus Louisville. You can head over to SportsLine to check out the picks. Here are several college football bets on the spread, money line and over/under for Louisville vs. Notre Dame:
- Spread Louisville vs. Notre Dame: Notre Dame -6.5
- Louisville vs. Notre Dame over/under: 45.5 points
- Moneyline between Louisville and Notre Dame: Notre Dame -250, Louisville +200
- Picks Louisville vs. Notre Dame: See picks on SportsLine
Why Notre Dame can provide coverage
Notre Dame’s offense has been firing on all cylinders since its 16-14 home loss to Northern Illinois. The Fighting Irish lit up the scoreboard in their 66-7 victory over Purdue on September 14 after an effective rushing attack. Quarterback Riley Leonard rushed for 100 yards and three scores against the Boilermakers, while running back Jeremiyah Love had 109 rushing yards and a touchdown on 10 carries.
For the season, Love is averaging 7.4 yards per carry, while Leonard has scored six rushing touchdowns. The Fighting Irish are averaging 238.2 rushing yards per game, the 18th best mark in college football. Defensively, Notre Dame is allowing 256.2 yards per game to opposing offenses, which ranks 16th in the nation. See here which team you should choose.
Why Louisville can provide coverage
The Cardinals are extremely explosive on offense, averaging 47.3 points per game, which ranks 12th in the nation. Louisville is led by quarterback Tyler Shough, who completes 68.4% of his passes for 850 yards, eight touchdowns and zero interceptions. In last week’s win over Georgia Tech, Shough completed 13 of 19 passes for 269 yards and two touchdowns.
Defensively, Louisville was tough to beat. The Cardinals are giving up an average of just 268.7 yards per game, which ranks 22nd in college football. Additionally, Louisville earned a 33-20 victory over the Fighting Irish in 2023, so the Cardinals will be confident they can overcome the upset on Saturday. See here which team you should choose.
How to make Louisville vs. Notre Dame picks?
The model has simulated Notre Dame vs. Louisville 10,000 times and the results are in. The model leans over the total and has also generated a point-spread choice that is successful in almost 60% of simulations. You can only see the pick at SportsLine.
So who wins Louisville vs. Notre Dame, and which side of the spread hits almost 60% of the time? Visit SportsLine now to see which side of the spread to jump on, all from the cutting-edge computer model that has risen more than $2,000 against the top-rated college football spreads since its inception, and find out.
